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Therefore, the intake of MG/AGEs can be reduced through the following dietary interventions: (I) Reducing the intake of exogenous MG/AGEs, such as avoiding high temperature processing (barbecuing, frying, baking), recommending low temperature cooking methods such as steaming, boiling, stewing, and reducing the intake of foods high in sugar and fat (such as processed foods, red meat, refined carbohydrates)

The primary BAs are then metabolized and transformed by the gut microbiota through a series of reactions, including deconjugation, dehydroxylation, oxidation and epimerization, to generate secondary BAs (Cai et al., 2022

Since anti-VEGF agents, the first-line treatment for age-related macular degeneration, required repeated invasive injections, mLP-CRISPR system achieved a 44% knockout of the VEGF-A gene with one single subretinal injection

Minor water retention or numbness in extremities at higher doses

When you combine them, you get a powerful synergistic effect