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When liver function deteriorates significantly, the combination of released stored B12, increased circulating haptocorrin, and reduced hepatic clearance can result in markedly elevated total serum B12 levels

The peptide is also a clinically proven and FDA-approved treatment

doi: 10.1021/acs.analchem.6b04727 96 DunnWBBroadhurstDBegleyPZelenaEFrancis-McIntyreSAndersonNet al

Although this finding requires further investigation with respect to the functional biomarkers Hcy and MMA, the finding opens the possibility of early identification of vitamin B 12 insufficiency or deficiency during the first trimester of pregnancy and adequate treatment

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