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Lenton KJ, Sane AT, Therriault H, et al

Adipose tissue macrophages: regulators of adipose tissue immunometabolism during obesity

Irritation and sensitivity Retinol alone can cause: Redness Peeling Dryness Burning sensation Increased sensitivity Adding peptides usually helps: Most peptides are soothing Support skin barrier repair Reduce inflammation When irritation occurs despite peptides: Reduce retinol frequency (every other night instead of nightly) Use lower retinol concentration (0.25% or 0.5% instead of 1%) Apply peptides in morning, retinol at night (not together) Add more moisturizer Take retinol break for few days pH incompatibility concerns The pH issue: Retinol works best at pH 5.5-6 Some peptides work best at different pH ranges Mixing products with very different pH can reduce effectiveness In practice: Modern formulations account for this Short contact time between layers minimizes pH issues Many successful products combine peptides + retinol in same formulation Solution: Don't worry excessively about pH

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An evidence-based update on nonsteroidal anti-inflammatory drugs