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10.1007/s00018-012-0988-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 2.Whitfield JB

756,776 The accumulation of lactate lowers the intracellular pH and inhibits effector T cells by reducing NFAT nuclear translocation and the activity of p38 and c-JNK/c-JUN

D.PrietoM.et al (2014)

However, like all substances, they should be used responsibly and under the guidance of a healthcare professional

Metformin, an AMPK activator, inhibits TGF-1-induced myofibroblast differentiation by promoting AMPK expression, leading to myofibroblast deactivation and apoptosis, reduction in the expression of type I collagen, fibronectin (FN), and -SMA in fibroblasts, and downregulation of ECM protein levels, thereby slowing or reversing PF (Rangarajan et al., 2018)