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In conclusion, although gabapentinoids and duloxetine are still widely used as first-line treatments for DPN, the adverse effects associated with their mechanisms of action have become key factors limiting their long-term clinical application

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coli favors ribbon isomer formation suggestion of a binding mode at the 7 nAChR

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Disclosures: Mengya Zang: Nothing to Disclose, Peilin Zhu: Nothing to Disclose, Qingxian Cai: Nothing to Disclose, Haojie Liao: Nothing to Disclose, Dayong Zheng: Nothing to Disclose, Feng Shi: Nothing to Disclose, Hualang Cai: Nothing to Disclose, Xuan Wu: Nothing to Disclose, QI Li: Nothing to Disclose, Huajin Pang: Nothing to Disclose 1809 THE HIPPO PATHWAY EFFECTOR TAZ IS REQUIRED FOR NOTCH-DRIVEN CHOLANGIOCARCINOGENESIS VIA METTL3-MEDIATED M6A MODIFICATION Wenbo Ma 1 Jinqiang Zhang 2 Weina Chen 1 Nianli Liu 2 Tong Wu 3 , 1 Tulane University School of Medicine, 2 Tulane University, 3 Tulane Medical Center Background: Notch and TAZ are implicated in cholangiocarcinogenesis, but whether and how these oncogenic molecules interact remain unknown