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Vitamin B12 plays a vital role in various bodily functions, keeping us energised and our body systems functioning properly

We extend beyond cataloging drugs by contextualizing landmark events such as the first biomarker-driven accelerated approval (tofersen) and a major Phase 3 trial failure leading to market withdrawal (AMX0035) to discuss their implications for clinical trial design and therapeutic strategy

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder caused by defects in hepatic glycoxidation metabolism, leading to excessive endogenous oxalate production

doi: 10.1053/j.gastro.2007.03.107 275

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