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Furthermore, some individuals carry mutations associated with defects in VitB12 metabolism but only experience complications later in life [15]

Thus, suitably designed formulations of resveratrol to fit the specific anticancer mechanisms and improved biopharmaceutical and pharmacokinetic properties are still needed to make resveratrol reasonable for clinical use in brain tumor management

10.1016/j.indcrop.2012.07.017 6 Amaral de BritoA

There is also the issue of muscle loss

Ferroptosis, an iron-dependent non-apoptotic cell death characterized by accumulation of lipid peroxides and ROS, has been shown to be associated with sleep deprivation and NRF2 pathway