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doi: 10.3389/fimmu.2018.00339 198 MorrisD.KhurasanyM.NguyenT.KimJ.GuilfordF.MehtaR.et al

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A disrupted barrier can result from over-cleansing, using harsh skincare products, nutritional deficiencies (especially in zinc, vitamin A, and omega-3 fatty acids), and gut imbalances

To elucidate the mechanism behind the beneficial effects of glutathione, further studies that examine the incorporation of orally administrated glutathione into the liver and the effects on the host redox system using stable isotope-labeled glutathione and animal models are required