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A similar reasoning can be used for autophagy modulation with lithium-based compounds, which was of no benefit in mouse models and had limited impact in human trials [88]

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It suppresses Erk1/2 and Akt phosphorylation generated by PDGF-BB

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With a higher proportion of senescent cells in the elderly, deficiencies in the respiratory chain functions may develop eventually and may be associated with a decline in mitochondrial respiratory efficiency [9]