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Meanwhile, in the outermost layer of the cornea, the epithelial cells possess tight junctions and efflux pumps that promote drug loss either by preventing paracellular drug permeation or inhibiting drug entry into the cell [28]

However, the presence of platelet tissue factor pathway inhibitor- can effectively inhibit the coagulation process, thereby reducing the severity of radiation-induced myocardial fibrosis [246]

While significant developments have been made in the field of hydrogel DDS, there are several barriers that impede the transition from research and development into clinical applications