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LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells

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doi: 10.3389/fphar.2021.767975 Received 02 September 2021 Accepted 11 October 2021 Published 26 October 2021 Volume 12 - 2021 Edited by Diego A

LRRK2 encodes a multi-domain protein containing a Roc GTPase domain and a serine/threonine-directed protein kinase domain, with PD-linked mutations known to enhance LRRK2 kinase activity and neuronal toxicity

Perinatal cytomegalovirus (CMV) infection has been suggested to be a possible cause or trigger of BA, in that CMV infection initiates damage to the bile duct, which is then followed by autoimmune responses targeting the bile duct