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Neuron 85 , 296302 (2015)

Cognitive Enhancement (Nootropic Properties): Semax may enhance memory and learning by upregulating brain-derived neurotrophic factor (BDNF) signaling in the hippocampus through the BDNF/TrkB pathway, which plays a key role in synaptic plasticity and long-term memory formation

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The results showed that tesofensine, particularly at a dose of 0.5 mg, led to a significant improvement in the total UPDRS score (-4.7 points) and a reduction in off time (-7.1%)