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In laboratory studies using HaCaT cellsa common model for investigating keratinocyte activation in psoriasisGPS effectively suppresses the release of inflammatory cytokines and chemokines when cells are exposed to TNF- and IFN-

In contrast, in the non-ubiquitin-mediated pathway, mitochondrial outer membrane proteins such as NIX, BNIP3, and FUNDC1 can directly bind to LC3 without undergoing ubiquitination (Tang and Dong, 2025

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To better understand such signaling mechanisms it is essential to be able to measure E GSH over a wide range from highly negative redox potentials down to potentials found in mutants that show already severe phenotypes