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Polycystic ovary syndrome (PCOS): international collaboration to translate evidence and guide future research

PloS Pathog (2015) 11(6):e1004911

All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress

The authors noted that GHK-Cu consistently demonstrated: 70% increase in collagen production in cultured human fibroblasts relative to untreated controls, observed at concentrations of 1-10 M

Furthermore, PRMT1 overexpression markedly shortened the half-life of CRIP1 (Fig