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In enteric neurons, morphine promotes a weak internalization of MOR compared to DAMGO as indicated above but chronic morphine exposure results in a significant increase in endocytosis (Patierno et al., 2011)

Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

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Using these and copper peptides together, especially at higher concentrations of either, compounds irritation risk