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In the nonenzymatic pathway, after a series of reactions, PUFAs produce lipid hydroperoxide (LOOH), 15-hydroperoxyeicosatetraenoic acid (15-HpETE), or 13-hydroperoxy-linoleic acid (13-HpODE), followed by the participation of transition metals, Hock rearrangement, and C-C C-H migration

Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation