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In one embodiment of this aspect, the method includes swallowing both the first and the second toothpastes following brushing

Percent cell death was determined as the percentage of PI-positive cells in the sampled population

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In fact, the treatment of healthy and tumor cells with CAP under conditions of selective tumor-cell death stimulates largely similar types of transcriptional response: the up-regulation of the p53 pathway, KRAS signaling, the UV response, TNF-alpha signaling, and apoptosis-related processes 99

The notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog