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Raucy JL, Carpenter SJ, Trzaskos JM

One naturally occurring peptide, Epithalamin, produced in the pineal gland, has been linked to increased melatonin production, enhanced immune and anti-carcinogenic functions in rodent models, and restoration of reproductive function in aged rodents

In the healthy brain, astrocytes contribute to tonic inhibition by synthesizing and releasing GABA through nonsynaptic mechanisms

each R is independently hydrogen or-CH 2 CH 2 C(O)OR B Each R B Independently is C 10-14 Alkyl radical, wherein R B Optionally substituted with one or more fluoro groups