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During angiogenesis, HIF-1 dominates early (EC proliferation, matrix degradation), whereas HIF-2 supports maturation (pericyte recruitment, vessel stabilization, extracellular matrix reinforcement)

doi: 10.1016/j.aquaculture.2017.08.013 10 LiJYLiXFXuWNZhangCNLiuWB

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Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients

For example, while effects of blood loss may be strictly linked to effects of decreased RBC count and volume, the pathological consequences of hemolytic anemia (which is mainly linked to a dysregulation of redox homeostasis or to hemoglobinopathies) may be related more closely to massive release of Hb in the circulation and its NO-scavenging properties