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Targeting the p53-FOXO4 Axis: In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death

demonstrated that increased HIF-1 expression and glycolytic activity in neutrophils suppresses their migration, apoptosis, and the release of ROS, MPO, antimicrobial peptides, and IL-8, effectively preventing excessive neutrophil activation and inflammatory damage during infection (Lu et al., 2021)

10.1016/j.tem.2017.05.001 186 VerkerkeA

What happens in the weeks before and after is largely in your hands

In senescent endothelial cells induced by OGD, treatment with FOXO4-DRI led to a significant increase in the expression of BAX and cleaved caspase-3 (c-Caspase-3), while the expression of BCL2 notably decreased