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Oral mucosal and epidermal melanocytes are histologically and ultrastructurally similar, but under physiological conditions, it seems that the former are intrinsically less metabolically active

Peer-review: Externally and internally peer-reviewed

Various methods to perform the biopsy include an elliptical excision or punch biopsy

Physiological oral mucosal melanin hyperpigmentation is very common in Blacks, in general is more frequent in darker-skinned than in lighter-skinned persons regardless of their race/ethnicity, and is most probably caused by genetically determined metabolic hyperactivity of oral melanocytes

Moreover, nasal sprays deliver peptides to the nasal passages in a precisely targeted manner, where they can affect either locally or systemically (e.g., in illnesses associated to the nose)