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Skin Rejuvenation & Anti-Aging (Collagen & Elastin Boosting) Dosage: 25 mg per day (subcutaneous injection) or 0.1%2% topical cream Cycle: Continuous use for 812 weeks, with a 4-week break Administration: Injectable: Best taken before bed for cellular repair Topical: Apply twice daily for skin improvement Stacking: With Epitalon for telomere extension and longevity With Thymosin Beta-4 (TB-500) for wound healing synergy With MOTS-c for mitochondrial skin regeneration Expected Benefits: Increased collagen and elastin production Reduction in wrinkles, fine lines, and sagging Improved skin hydration, firmness, and texture 2

Concurrently, mitochondrial dysfunction and oxidative stress exacerbate inflammaging via mitochondrial reactive oxygen species (mtROS), which not only trigger NLRP3 inflammasome activation and IL-1 maturation but also suppress SIRT1 deacetylase activity, further reinforcing NF-B-driven inflammatory cascades 43

fasting insulin is not a standard NHS test and is reserved for specialist scenarios such as unexplained hypoglycaemia or metabolic syndrome assessment

These findings highlight an emerging gutimmunebrain pathway that may be targeted to improve stroke recovery