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With the deepening of studies on the mechanism of ferroptosis, it has been found that ferroptosis plays a role in various biochemical reactions such as cell growth, energy metabolism, and DNA synthesis repair, which are associated with the development of lung diseases ( Figure 1 In this paper, the mechanism of ferroptosis, the research progress of ferroptosis in a variety of lung diseases, and the related signaling pathways and proteins are targeted to provide new ideas and insights for the prevention and treatment of lung diseases in clinical practice ( 2 Characteristics and mechanisms of ferroptosis 2.1 Iron overload Iron is an essential trace element in the body, and iron overload is a key factor in the development of ferroptosis ( 3+ to Fe 2+ during iron metabolism ( Figure 2 )

This is consistent with the fact that examination of the fatty-acid oxidation pathway in fibroblast culture did not reveal any abnormalities to explain the elevations in acyl-carnitines

The good news is that human research on the metabolic and longevity aspects of intermittent fasting is burgeoning as of late, and preliminary evidence is generally promising

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