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A second significant response to chronic tobacco smoke exposure is the generation of reactive oxygen species (ROS), which overwhelm the cellular antioxidant defense system, primarily centered around glutathione (GSH) [11, 12]

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Glutathione depletion causes cell growth Inhibition and enhanced apoptosis in pancreatic cancer cells

TABLE 1 Advantages and disadvantages of 2D and 3D-cell cultures as model of neurodevelopmental and neurodegenerative diseases and mitochondrial disorders