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The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration

Subsequent assessments of mitochondrial function demonstrated that PX-478 treatment severely impaired mitochondrial activity, as evidenced by decreased ATP-linked OCR, reduced MMP, and lower ATP levels (Fig

Toxicology 227 , 94104 (2006)

Creatine is crucial for energy production within the cells

Extended Results (Optional): Additional metabolites such as -glutamylcysteine, cysteine/cystine, NADPH/NADP, and selected glutathione conjugates if requested