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Conditional deletion of the mitochondrial transcription factor A (Tfam) in CD4 + T cells led to an imbalance in the NAD + /NADH ratio of mitochondria, which induced metabolic reprogramming toward glycolysis and thereby contributed to their pro-inflammatory phenotype, consequently exacerbating the in vivo immune response

Mol Ecol 28(13):31973207 Tanase DM, Gosav EM, Neculae E, Costea CF, Ciocoiu M, Hurjui LL, Tarniceriu CC, Floria M (2020) Hypothyroidism-induced nonalcoholic fatty liver disease (HIN): mechanisms and emerging therapeutic options