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Further, in certain embodiments, the linker may be maleimidocaproyl (mc)

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Interestingly, chronic inflammation leads to the upregulation of the key UPR sensor PERK by downregulating the expression of histone acetyltransferase lysine acetyltransferase 6B (known as MORF), which leads to the sustained activation of UPR in PDLSCs and aggravates the inhibition of osteogenic differentiation in vivo and in vitro (185)

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