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(2/)ROS-targeting therapies were tested

Ren Y, Guo F, Wang L

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4.4.1 Glutamine Glutamine metabolism not only promotes the synthesis of succinic acid by fueling the TCA cycle in M1-type macrophages, but also drives M2 polarization via the conversion to glutamate and then -KG, with high -KG levels and a high -KG/succinate ratio facilitating macrophage reprogramming towards the M2 phenotype (Liu et al., 2017)