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Repeat numbers exceeding 200 tandems trigger the epigenetic silencing of FMR1 by initiating an abnormal 5-C-phosphate-G-3 methylation and repressive Histone modifications in the promoter region (e.g., Coffee et al., 1999, 2002

In other words, sensitive and correct assay methods for screening and development of effective tyrosinase inhibitors are of great importance

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Haptoglobin genotype and vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis in China: a multicenter, randomized, placebo-controlled trial design