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While the first studies showing this were in mice [14], human studies have corroborated these findings [200], although its importance in relationship to traditional clearance pathways across the BBB and subarachnoidal granulations has been challenging to quantify

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In general, Yinchenhao Decoction consists of several herbal medicines, including Herba Artemisiae Scopariae, Fructus Gardeniae, Radix et Rhizoma Rhei, etc., among which Herba Artemisiae Scopariae act as the principal ingredient

In the context of this review, it is worth mentioning that copper is a transition metal that can exist in both oxidation and reduction states