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Key Takeaways MK-677 increases endogenous growth hormone and IGF-1, supporting recovery, sleep, and lean mass retention

Under nutrient deprivation conditions, ULK1 is stimulated and Atg13, FIP200 and ULK1 itself are phosphorylated, resulting in the recruitment of other autophagy proteins for phagophore nucleation and assembly (28)

Macias-Velasco, Subhadra Gunawardana, Mario A

Briefly, behavioral testing was conducted using the StartleMonitor/AuxAmp II system (Kinder Scientific, LLC), where animals were placed in a sound-attenuating box equipped with two ceiling-mounted loudspeakers and a floor-mounted piezoelectric transducer platform

Farhan et al., 2023