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Similarly, PTC Therapeutics leveraged a splicing-focused drug discovery platform to develop compounds mimicking branaplams mechanism

2016 May;31(5):706-13

Target: 150200 mg daily by Weeks 38

J., & Berk, M

Unlike fatty acid metabolism, which is primarily controlled by SREBP-1c, cholesterol homeostasis is governed by SREBP2, a transcription factor that senses intracellular cholesterol levels and modulates cholesterol synthesis, uptake, and storage accordingly [50]