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COVID-19 patients also display diffused white matter damage, microglial activation, and neuroinflammation at different CNS regions with olfactory neuritis (25%), nodular brainstem encephalitis (31%), and cranial nerve neuritis (6%) 199

Alfentanil is demethylated by CYP3A4 and may be a useful CYP3A probe due to the pupillary response to alfentanil (Klees et al., 2005)

In patients with endometriosis, progesterone resistance is observed, possibly related to a decrease in PRB levels [86], which tends to inactivate progesterone target genes, leading to inflammation and deficient estrogen metabolism [87]

While Turner et al.s primary results suggested that resveratrol has potential in slowing functional decline, other clinical assessments, including the Clinical Dementia Rating-Sum of Boxes, ADAS-cog, MMSE, and Neuropsychiatric Inventory do not reflect this effect [77]

4,5 GM-CSF is produced by both hematopoietic (eg, T cells, B cells, macrophages, monocytes) and some viscerosomatic cells (type II alveolar epithelial cells, endothelial cells, fibroblasts) and can activate cells through the dimeric GM-CSF receptor expressed primarily on monocytes and macrophages but also on dendritic cells and other cells of the innate immune system (Figure 2A)