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Systemic Inflammation: Curcumin's ability to inhibit the NF-B pathway helps downregulate the systemic production of pro-inflammatory cytokines (like IL-6 and TNF-), addressing the immune hyperactivation seen in Long COVID and MCAS

doi: 10.1111/febs.14192

However, a growing body of evidence points to a role for G6PD-d in pathologies other than hemolysis, including atherosclerotic cardiovascular disease (ASCVD)

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is a crucial pro-ferroptotic regulator by catalyzing the synthesis of long-chain polyunsaturated CoAs, especially arachidonic acid, thus enriching cellular membranes with PUFA (Yuan et al., 2016b

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