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Curr Gastroenterol Rep

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

A sophisticated afferent innervation transmits sensory data from the digestive system to the central nervous system (CNS), facilitating the coordination and integration of gut reflex functions and associated behavioral responses

Since B12 is water-soluble, your body excretes what it doesnt use, making it generally safe, even in higher doses [*]

In many cases, synthetic vitamins are chemically identical to those found in food and can provide the same benefits when properly absorbed by the body