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Under this condition, HIF-1 becomes stabilized and subsequently translocates to the nucleus, where it binds to hypoxia-responsive elements within target genes, thereby promoting metabolic programming, notably the upregulation of anaerobic glycolysis (37,38)

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Despite the high basal level of FTL in macrophages, we found FTL signals outside of macrophage markers (CD68 and CD11c) in severe COVID-19 lungs, suggesting that other alveolar cell types were involved in FTL upregulation (Supplementary Fig

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