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It usually involves difficult or irregular bowel movements, accompanied by hard, dry motions which can be painful to pass

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Excluded from the study were subjects taking any oral or topical prescription drug for acne vulgaris, subjects cur- rently undergoing treatment for acne vulgaris besides daily hygienic skin care, known renal or hepatic impair- ment, scheduled elective surgery or other procedures requiring general anaesthesia during the study, participa- tion in another research study involving an investiga- tional product in the past month, hypersensitivity or known allergy to any ingredients in the study agent, cur- rent use of any dietary supplement for skin health (be- sides a multivitamin), history or presence of gastric ulcer or duodenal ulcer, history of any gynaecologic condition, history of any psychiatric disorder and current smoking or smoking within the past month

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