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PEX2 can ubiquitinate PEX5, thereby activating NBR1-dependent pexophagy (Sargent et al., 2016)

Further, -LA can provide additional antioxidant effects by recycling both vitamin C and vitamin E (Coombes et al., 2000)

Heredity seems to play a part, and the onset of symptoms seems to coincide with times of significant hormonal upheaval, such as during puberty, pregnancy and menopause (Szel et al, 2014)