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and Schroder K., NLRP3 Inflammasome Activation: The Convergence of Multiple Signalling Pathways on ROS Production?, Nature Reviews Immunology 10, no

El-Beltagy et al

This is the level of safety data appropriate for early preclinical research, not for human use

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Tirzepatide has been studied across a wide range of body weights (from 40 kg to over 200 kg), with only minor differences in exposure that are not clinically significant enough to warrant dose modifications