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Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis

The benefits typically last 1 to 2 weeks

Kraus, D., et al

This selective mechanism produces metabolic safety benefits that may make AOD-9604 appropriate for individuals who cannot tolerate or have contraindications to conventional growth hormone therapy

Heterodimeric interaction between retinoid X receptor and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation