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[55] In individuals with obesity, chronic low-grade inflammation often leads to "leptin resistance"a pathological state where circulating leptin levels are high, but the brain fails to register the signal, leading to persistent hunger

A few anecdotal reports suggest intra-articular injections for joint conditions, but these lack controlled data

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Other research has shown that omega-3s improve nerve structure in diabetes, and they are considered safe at daily doses of up to 3 grams of combined EPA and DHA