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TOXICOLOGY: The oral LD50 for laboratory rats was greater than 5000 mg/kg of body weight

Ideally, blood tests (including full blood count, serum B12, folate, and possibly anti-intrinsic factor antibodies if pernicious anaemia is suspected) should be performed before starting supplements, as supplementation can affect test results

Horses : 1 mL/15 kg bodyweight (30 mL/450 kg)

However, such combined supplementation did not reduce depression risk among middle-age and older women despite significant reductions in homocysteine levels (41)

Elevated NNMT activity has been associated with increased fat accumulation, reduced metabolic efficiency, and impaired cellular energy production