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Concurrently, pro-inflammatory cytokines regulate the activity of key enzymes in tryptophan metabolismindoleamine IDO and TDOpromoting the production of kynurenine pathway metabolites such as KYNA

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Asp800 stabilizes the ion-pair reactant state To identify critical residues in EGFR that contribute to the formation of the ionpair state R1 and the final adduct state, we performed the interaction energy decomposition analysis