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In this context, DMF promotes Th2 cell differentiation, with immunoregulatory functions ( In summary, the rationale of employing DMF in psoriasis consists in reducing cellular inflammation both by decreasing glutathione intracellular levels and by inducing a switch in immune response toward an anti-inflammatory/immunoregulatory setting ( The Role of Small Molecules in the Metabolic Syndrome Patients with psoriasis are characterized by a higher prevalence of cardiovascular disease and metabolic syndrome ( Funding This study received funding from Almirall S.p.A

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doi: 10.1016/j.coi.2013.10.010 17 HuMLiaoKLeiWZhangRTuC

The literature reveals that Nrf2 plays a role in the development and progression of gliomas with isocitrate dehydrogenase mutations, further confirming an interplay between oxidative stress and isocitrate dehydrogenase mutations [26]

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