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Nat Med 7(8):947953

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3.1.2 Relationship between lipid metabolism and ferroptosis PUFAs, particularly those containing bis-allylic hydrogen atoms such as arachidonate (AA) and adrenate (AdA), are highly susceptible to oxidation by ROS, making them central to ferroptosis (81)

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i) Primary Pharmacological Actions of 5-Amino-1MQ: No It is not a neurotransmitter agonist 5-Amino-1MQ does not bind to or activate any known: Dopamine receptors Serotonin (5-HT) receptors GABAA or GABAB Cholinergic or adrenergic receptors Primary Mechanism of Action Inhibition of NNMT (Nicotinamide N-Methyltransferase) Main action : Inhibits NNMT, an enzyme that methylates nicotinamide (vitamin B3 derivative)