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Phthalates, which are common plasticizers and endocrine-disrupting chemicals, are released from polyvinyl chloride (PVC) microplastics and are a cause of concern

This occurs through the action of mobilized FAs that function as allosteric activators of uncoupling protein 1 (UCP1), the molecular mechanism for heat generation in brown fat (6, 100)

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It can be observed that proglucagon is not expressed by a single gene, but is embedded in a larger gene, and when this large gene expresses a large peptide chain (called preprohormones), it is then cleaved by specific enzymes and post-translationally modified to finally obtain fragments with different biological activities