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In such scenarios, directional selection is more effectively reflected by a diminished level of genetic variation, rather than the traditional Hardy-Weinberg equilibrium (HWE) expectations [65]

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International Journal of Medical Sciences, 12(1), 10-25

Infertility or recurrent miscarriage [5] Understanding MTHFR Gene Variants Two well-documented MTHFR polymorphisms have significant clinical implications: C677T Variant (rs1801133): Homozygous individuals may experience a 70% reduction in enzyme activity , leading to increased homocysteine levels and an elevated risk of cardiovascular disease, miscarriage, and neural tube defects [4]