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Some flavonoids can act as pro-oxidants, which means that they have the potential to generate ROS and exhibit mutagenic and genotoxic effects in certain experimental systems [299]

[DOI] [PubMed] [Google Scholar] 92.Bourgonje A.R., Feelisch M., Faber K.N., Pasch A., Dijkstra G., van Goor H

2 Effect of the gut microbiome on neural interactions The majority of the microbial species accommodated in the human body are found in the large intestines, where they can disrupt the availability and absorption of nutrients and may impact the homeostasis of the host system (53)

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The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer