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In: SrivastavPPGuptaRKKarunanithiS, editors

Mechanistically, MAGI3 binds -catenins C-terminus via PDZ domains, disrupting intramolecular N-terminusARM domain interactions to expose phosphorylation sites, thereby enabling GSK-3mediated -catenin phosphorylation and ubiquitin-dependent degradation

Metformin shows promise for this population as well

Remarkably, gut bacteria contribute over 60% of colonic and circulatory 5-HT pools, while stimulating enterochromaffin cells to release 5-HT that activates immune cells and neurons, ultimately influencing mood and cognition (Roth et al., 2021)