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Hakam notes that preclinical and laboratory studies suggest it is more stable in gastric acid than many other peptides

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Nature 574 , 717721 (2019)

Interestingly, the predicted HfasTerp104 gene cluster includes enzymes that are likely responsible for the synthesis of 3,5-D, including the benzoic acid reductase-PKS, SDR, glycoside hydrolase, and the multifunctional 3-phosphoshikimate-1-carboxyvinyltransferase